Infliximab alleviates inflammation and ex vivo airway hyperreactivity in asthmatic E3 rats

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Infliximab alleviates inflammation and ex vivo airway hyperreactivity in asthmatic E3 rats.

Tumor necrosis factor-α (TNF-α) has been implicated in the pathogenesis of asthma, and neutralization of TNF-α is an effective therapy for inflammatory diseases. The present study tested the idea that a TNF-α antibody, infliximab, may be useful in the management of asthma. E3 rats were immunized with ovalbumin (OVA)/alum and received infliximab intra-peritoneally. Two weeks later, OVA-PBS was i...

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ژورنال

عنوان ژورنال: International Immunology

سال: 2011

ISSN: 0953-8178,1460-2377

DOI: 10.1093/intimm/dxr032